Nicalis just announced The Binding of Isaac: Repentance, and while we got a trailer, we still have no clue what this actually is right now.
The 19 second trailer gives us a logo for what we assume is a game, but not much else. We do know, however, that it will be at booth 233 at PAX West. Its presence at PAX suggests that is in fact a video game, but we can’t say that for certain.
So, without any other information, I welcome your wild and wacky guesses about what this is.